Histological Evaluation of Wound Healing Potential of Aqueous Extracts of Tamarindus indica Seed Extract in Wistar Rats

Authors

  • M.O. Mohammed Department of Histopathology, School of Medical Laboratory Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto Author
  • O. Angbagh Department of Histopathology, School of Medical Laboratory Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto Author
  • A.T. Muhammad Department of Histopathology, School of Medical Laboratory Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto Author
  • I. Mohammed Department of Histopathology, School of Medical Laboratory Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto Author
  • U. Abubakar Department of Histopathology, School of Medical Laboratory Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto Author
  • A. Salihu Department of Morbid Anatomy and Forensic Medicine, College of Health Sciences, Usmanu Danfodiyo University, Sokoto Author
  • A. Umar Department of Histopathology, School of Medical Laboratory Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto Author
  • M. Bello Department of Chemical Pathology, School of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto Author
  • A.O. Iyiola Department of Histopathology, Usmanu Danfodiyo University Teaching Hospital, Sokoto. Author
  • Y.A. Isah Department of Histopathology, School of Medical Laboratory Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto Author

DOI:

https://doi.org/10.4314/jeca.v21i1.12

Keywords:

Histological, Wound, Healing, Tamarindus indica, Wistar rats

Abstract

BACKGROUND AND AIM: Tamarindus indica has been used as a traditional medicine for various purposes. Wound healing is a complex process that involves a series of immunological and biological events. This study aimed to evaluate the wound healing potential of Tamarindus indica seed extract in Wistar rats.

METHODOLOGY: The study involved creating a 1.5cm full thickness wound on the dorsal region of 16 healthy Wistar rats. After the excision of the wound, the animals were grouped into four (4) groups (A, B, C and D) of four animals per group. Untreated, Silver Sulphadiazine, 1% Tamarindus indica seed extract and 2% Tamarindus indica seed extract were respectively applied to group (A, B, C and D) for the period of 13 days.  And the histological analysis of the wound area was performed on the 14th day.

RESULTS: The results showed that 2% of aqueous Tamarindus indica seed extract   significantly improved wound healing rates and was better in term of efficacy when compared to the standard drug (Silver Sulphadiazine). It also enhanced the cellular proliferation, blood vessel formation, epidermal regeneration, granulation tissue formation, and collagen formation.

CONCLUSION: The study revealed that Tamarindus indica seed extract had wound healing potential, and that the effect was dose dependent.

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Published

2024-06-30

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Section

Original Articles

How to Cite

Histological Evaluation of Wound Healing Potential of Aqueous Extracts of Tamarindus indica Seed Extract in Wistar Rats. (2024). Journal of Experimental and Clinical Anatomy, 21(1), 78-83. https://doi.org/10.4314/jeca.v21i1.12