Neurobehavioral and histological effects of Akaki extract on the temporal lobe: Mimicking traditional treatment method

Abstract

Introduction: Neurobehavioral and histological effect of akaki extract on the temporal lobe of wister rats was carried out. In the study we evaluate a traditional prescription method for the treatment of mental illness using the akaki extract on the temporal lobe. Material and Methods: Twenty rats of average weight 200 g were divided into four groups (n = 5). The rats in the control group (GroupA) were given feed and water, while the rats in the experimental Groups B, C, and D were treated daily with 3 mg/kg, 6 mg/kg and 9 mg/kg of the extract for 7days respectively. Results: Preliminary phytochemical analysis revealed presence of bioactive agents.The behavioral study was performed using the elevated plus‑maze (EPM) to access anxiety and routine H and E histological technique. The mean difference was significant at level (P < 0.05). The study showed that the rat exhibited antianxiety property in the EPM. This was more pronounced in the experimental rats. The histological study performed showed that there were progressive changes in the temporal lobe integrity of the sections of the rat in the experimental groups with the rat that received 9 mg/kg of the Akaki extract showing more prominent features of these changes which include cytoplasmic vacuolations and eccentric nuclei within the pyramidal cell layer than granular cell layer as compared to the control group (Group A). Conclusion: In conclusion, the akaki extract shows positive indication of its use in the treatment of mental illness.