Histological evaluation of the antidyslipidemic effects of aqueous root extract of Morinda lucida

Authors

  • O.S. Innih Department of Anatomy, School of Basic Medical Sciences, College of Medical Sciences, University of Benin Author
  • J.O. Owolabi Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin, Nigeria. Author
  • D.C. Ekpruke Department of Physiology, School of Basic Medical Sciences, College of Medical Sciences, University of Benin Author

DOI:

https://doi.org/10.4103/jeca.jeca_16_18

Keywords:

Antilipidemia, atorvastatin, Morinda lucida

Abstract

BACKGROUND: Dyslipideamia is involved in the development of cardiovascular complications in diabetes, which is one of the major causes of morbidity and mortality in Nigeria.
AIM AND OBJECTIVE: The present study was undertaken to investigate the antidyslipidemic effect of aqueous root extract of Morinda lucida in cholesterol‑induced dyslipidemia in rats.
MATERIALS AND METHODS: The study comprises of five groups, Group 1 for control and 2, 3, 4 and 5. They were administered different doses of drug and extract by oral gavages using an orogastric tube at a once‑daily dose for 14 days. At the end of 14 days, liver and abdominal aorta was harvested from rats in each group for histological study using the method.
RESULTS: It was observed that Group 3 showed intracytoplasmic perinuclear fat vacuoles in the liver among other evidences of tissue damage while the abdominal aorta showed luminal obstruction, infiltrates of chronic inflammatory cells, and intimal ulceration. 
CONCLUSION: These effects were ameliorated after treatment with both atorvastatin and M. lucida extract, but there was more improved histology in the group treated with M. lucida extract. 

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Published

2018-06-29

Issue

Section

Original Articles

How to Cite

Histological evaluation of the antidyslipidemic effects of aqueous root extract of Morinda lucida. (2018). Journal of Experimental and Clinical Anatomy, 17(1), 23-28. https://doi.org/10.4103/jeca.jeca_16_18