Amlodipine Besylate Is Testes Friendly

Abstract

Amlodipine besylate is a relatively new antihypertensive drug with potential as a choice chemotherapy in future. Commonly prescribed as a single oral dose, it can be used in all forms of elevated blood pressure and as a high cure rate. Eleven (11) male Wistar rats of 250g average body weight were used to determine the effect of Amlodipine besylate on the testes. Three dose levels (0.5, 1.0and 10mg/kg) were used. The rats were all sacrificed on the eighth day following treatment and the testes examined morphologically and histologically after fixing with 10% formaldehyde. The results obtained revealed active seminiferous tubules where the processes of spermatogenesis and spermiogenesis were seen occurring. This study strongly suggests that there was no toxicological effect on the testes even at dose level as high as 10mg/kg. It could be deduced that Amlodipine besylate is a very safe drug which is highly recommended.