Haematological Changes Following Vitamin E Supplementation During Caffeinated and Non-Caffeinated Paracetamol Administration In Rats

Abstract

Haematological changes associated with caffeinated and non-caffeinated paracetamol administration with or without Vitamins A and E supplementation was investigated in albino Wistar rats using panadol extra and paracetamol as caffeinated and non-caffeinated paracetamol respectively; and water soluble acetic acid derivatives of Vitamin E. administration of paracetamol alone caused a significant increase (P <0.05) in Hb compared to the control while and Panadol extra + vitamin E caused a significant decrease (P<0.05) compared to paracetamol group. The PCV significantly decreased ((P<.0.05) in the paracetamol + vitamin E group, while the RBC count significantly decreased in the Panadol extra + vitamin E group compared to the paracetamol group. Caffeinating, vitamin E produced significant decrease (P <0.05) in WBC count when co-administered with paracetamol compared to the group on paracetamol alone. The result suggests that administration of paracetamol without caffeinating or supplemented with vitamins E may result in anemia and leukocytosis, and supplementation with vitamins E may play a role in remitting these adverse changes. However, administration of vitamin E tended to potentiate the adverse hematological changes during caffeinated paracetamol therapy.