Acute Toxicological Effects of Crude Oil on Haematological and Biocheinical Parameters in Guinea Pigs

Abstract

The acute toxicological effects of Brass blend of crude oil on the haemoglobin concentration, and Liver functions in the Guinea pig were studied. 25 Guinea pigs divided into five animals per group were used for the study. They were divided into 5 groups. One group served as a control group, while the others received varying doses of crude oil intra-peritoneally. After 24 hours of the administration, the following parameters were assayed; haemoglobin concentration, serum bilirubin levels, and serum Liver enzymes; aspartate transaminase, and alanine transaminase. Results show a dose dependent decrease in the haemoglobin concentration, while the bilirubin and enzyme levels in the blood increased in a dose dependent pattern, suggesting some degree of haematologic and hepatic pathology.