Acute Toxicity Determination of Pyrrolobenzothiazine and Pyrrolobenzoxazine Ring Systems on Mice

Abstract

Toxicity tests were carried out on two Bezethiazine and Benzoxazine derivatives. For this experiment, a total of sixty (60) Albino mice with average weight range 18-26g were employed. For each test compound, thirty (30) mice were distributed in five cages and fed ad libitum for 14 days for acclimatization. The test compounds were suspended in a non-toxic solvent (Tween 80) and intraperitoneally administered into the mice at doses of 450mg/kg, 500mg/kg, 550mg/kg and 600mg/kg. The results showed that the compound pyrrolobenzothiazine ring system has a LD₅₀ value of 500.00mg/kg, while the compound pyrrolobenzoxazine ring system has an LD₅₀ value of 517.60mg/kg. These results are indicative of low toxicity values for the two compounds.