Ovarian Weight Evaluation in Hyperprolactin Female Sprague-Dawley Rats treated with Green Coconut Water

Abstract

BACKGROUND: Ovarian weight change has long been used as a sensitive indicator of chemically induced changes in reproductive organs and processes.
AIM: This study was carried out to determine the effect of green coconut water on ovarian weight in hyperprolactin female Sprague- Dawley rats.
MATERIALS AND METHODS: The study was divided into 6 study groups (A- F). In study group A, metoclopramide hydrochloride was administered and this was used to experimentally induce hyperprolactinaemia at 0.2mg/100g body weight/day through oral route for 28days and this was withdrawn for 8, 16 and 28days. The study group B was post-treated with 5 ml/100 g. b. w. and 10ml/100gbw of green coconut water following the administration of metoclopramide hydrochloride. In study group C, animals were co-administered with 0.2mg/100g body weight of metoclopramide and 5ml/100gbw of green coconut water and 10ml/100gbw of green coconut water. In study group D, animals were pre-treated with 5ml/100gbw and 10ml/100gbw of green coconut water prior to the administration of metoclopramide hydrochloride while study group E animals received 5 ml/100 g. b. w. and 10ml/100gbw of green coconut water only. The study group F received distilled water only.
RESULTS: There were gradual increase in ovarian weights with increase in the number of days of post-treatment with green coconut water in hyperprolactin rats.
CONCLUSION: Green coconut water causes increase in ovarian weight in hyperprolactin rats which may be attributed to its estrogenic property and consequent stimulation of ovarian follicles.